Authors: Maria Fernanda Noriega-Iriondo1, Gerardo Colon-Otero2*, Benjamin R Kipp7, John A Copland6, Matthew J Ferber7, Laura A Marlow6, Maegan E Roberts2, Matthew W Robertson3, Tri A Dinh3, Steven Attia2, Xochiquetzal J Geiger4 and Douglas L Riegert-Johnson5
A 46-year-old female presents with a pelvic mass and is diagnosed as having a high-grade endometrial stromal sarcoma. During surgery, she is noted to have areas of intussusception of the small bowel secondary to large hamartomatous polyps. The patient had a previous history of small bowel obstruction secondary to what had been thought to be hyperplastic polyps but represented hamartomatous polyps on further review. Additional examination revealed the presence of subtle hyperpigmented macules on the fingers leading to a diagnosis of Peutz-Jeghers Syndrome (PJS). The diagnosis was confirmed by the presence of a germ-line STK11 mutation. Immunohistochemistry analysis of the tumor showed decreased expression of STK-11 as compared to one of the patient?s hamartomatous polyps. Next generation sequencing of the tumor specimen failed to demonstrate a ?second hit? somatic mutation in STK-11. This case represents the first case of endometrial stromal sarcoma associated with PJS and illustrates the importance of increased awareness of this condition among oncologists. PJS is associated with dysregulation of the mTOR pathway; treatment with an mTOR inhibitor was not effective in this case.
Published: 23 January 2015
Link to article: http://www.hccpjournal.com/content/13/1/6/abstract