Endometrial stromal sarcoma: prognostic factors and impact of adjuvant therapy in early stages

SOURCE:

Tanz R, Mahfoud T, Bazine A, Aassab R, Benjaafar N, El Gueddari, Bel K, Ichou M, Errihani H. Endometrial stromal sarcoma: prognostic factors and impact of adjuvant therapy in early stages. Hematol Oncol Stem Cell Ther 2012;5(1):31-35. Link to abstract

DOI: 10.5144/1658-3876.2012.31

BACKGROUND AND OBJECTIVES: Endometrial stromal sarcomas (ESS) are rare uterine neoplasms. Surgery remains the cornerstone of treatment for early stages and consists of an abdominal hysterectomy with bilateral salpingo-oopherectomy. Despite appropriate surgical treatment, relapse rates are high (18% to 45%) and the value of adjuvant therapies is not clear. We evaluated prognostic factors and the impact of adjuvant treatment on localized ESS (stages I and II).

DESIGN AND SETTING: Retrospective, case-control study conducted at the National Institute of Oncology in Rabat, Morocco over 10 years from 2000 to 2009.

PATIENTS AND METHODS: Twenty-one cases of localized ESS were included in the analysis.

RESULTS: Standard surgery was performed in 71.4% of our patients. Myometrial invasion was noted in 57.1% of cases. Mitotic activity was considered high in five patients. Adjuvant treatment was given to 52.3% of patients: endocrine therapy in five patients and radiotherapy in six. Survival was significantly longer in the group of patients who underwent standard surgical treatment (P=.0007), in the absence of deep myometrial invasion (P=.0248) in cases with a low mitotic index (P<.0001) and in patients who received adjuvant therapy (hormone or radiotherapy) (P=.0048). In a multivariate analysis independent risk factors for monitoring were inadequate surgical treatment and absence of adjuvant treatment.

CONCLUSIONS: Myometrial invasion and mitotic index appear to be important prognostic factors. The reference surgery is hysterectomy with bilateral salpingo-oopherectomy. Lymph node dissection does not appear to provide a benefit. Finally adjuvant treatment may carry a significant survival benefit.