Radiation Therapy in Addition to Gross Total Resection of Retroperitoneal Sarcoma

From the Journal of Oncology
Volume 2008 (2008), Article ID 824036, 11 pages
http://www.hindawi.com/journals/jo/2008/824036.html

 

Abstract


Purpose. Typical treatment of retroperitoneal sarcomas (RPSs) is surgery with or without radiation therapy for localized disease.  With surgery alone, local failure rates are as high as 90%; this led to radiation therapy playing an important role in the treatment of RPSs. Methods. Thirty-one patients with retroperitoneal sarcoma treated with gross total resection and radiation therapy make up this retrospective analysis. Nineteen were treated preoperatively and 12 postoperatively (median dose, 59.4 Gy)—sixteen also received intraoperative radiation therapy (IORT) (median dose, 11 Gy).  Patients were followed with stringent regimens, including frequent CT scans of the chest, abdomen, and pelvis. Results. With a median follow-up of 19 months (range 1–66 months), the 2-year overall survival (OS) rate is 70% (median, 52 months).  The 2-year locoregional control (LRC) rate is 77% (median, 61.6 months).  The 2-year distant disease free survival (DDFS) rate is 70% (median not reached).  There were no differences in radiation-related acute and late toxicities among patients treated pre- versus postoperatively, whether with or without IORT. Conclusions. Compared to surgery alone, neoadjuvant or adjuvant radiation therapy offers patients with RPS an excellent chance for long-term LRC, DDS, and OS. The integration of modern treatment planning for external beam radiation therapy and IORT allows for higher doses to be delivered with acceptable toxicities.

Radiotherapy improves endometrial cancer

Source: The European Cancer Conference; Barcelona Spain: 23-27 September 2007

Assessing the quality of life of patients with endometrial cancer who receive vaginal brachytherapy


MedWire News: Preliminary results from this year's European Cancer Conference in Barcelona, Spain, suggest that vaginal brachytherapy can improve the quality of life (QoL) of endometrial cancer patients.

Remi Nout (Leiden University, The Netherlands) and colleagues analyzed the responses of 427 patients on a QoL questionnaire, who were randomly assigned to receive vaginal brachytherapy or external beam pelvic radiotherapy. The questionnaires were completed before and after treatment, and every 6-12 months for up to 5 years.

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